17346786 Dataset Description
Display information related to the dataset used on the piRNA search processing and stored on piRNAdb. Basic statistics, like access code and piRNAs found in this dataset are available. Also information about the title, authors and abstract of the published paper. In the end is provided a list of all piRNAs, and their links, that were found in this dataset.
To get more information about how we select the datasets that will be part of piRNAdb, access the specific page "About", item: Dataset Selection Criteria
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- Dataset Code
-
17346786
- Serie
- Organism
- Drosophila melanogaster
- Method
- Immunoprecipitation
- Tissue
- ovary
- Quantity piRNA
-
20702
17346786 Pubmed Informations
Retrieved from Pubmed website
- Title
- Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.
- Publication Date
- 05/08/2007
- Abstract
- Drosophila Piwi-family proteins have been implicated in transposon control. Here, we examine piwi-interacting RNAs (piRNAs) associated with each Drosophila Piwi protein and find that Piwi and Aubergine bind RNAs that are predominantly antisense to transposons, whereas Ago3 complexes contain predominantly sense piRNAs. As in mammals, the majority of Drosophila piRNAs are derived from discrete genomic loci. These loci comprise mainly defective transposon sequences, and some have previously been identified as master regulators of transposon activity. Our data suggest that heterochromatic piRNA loci interact with potentially active, euchromatic transposons to form an adaptive system for transposon control. Complementary relationships between sense and antisense piRNA populations suggest an amplification loop wherein each piRNA-directed cleavage event generates the 5' end of a new piRNA. Thus, sense piRNAs, formed following cleavage of transposon mRNAs may enhance production of antisense piRNAs, complementary to active elements, by directing cleavage of transcripts from master control loci.
- Author(s)
- Brennecke, Julius; Aravin, Alexei A; Stark, Alexander; Dus, Monica; Kellis, Manolis; Sachidanandam, Ravi; Hannon, Gregory J;