22313525 Dataset Description

Display information related to the dataset used on the piRNA search processing and stored on piRNAdb. Basic statistics, like access code and piRNAs found in this dataset are available. Also information about the title, authors and abstract of the published paper. In the end is provided a list of all piRNAs, and their links, that were found in this dataset.
To get more information about how we select the datasets that will be part of piRNAdb, access the specific page "About", item: Dataset Selection Criteria

Display More Information...

• Dataset Code
• 22313525
• Serie
• Organism
• Homo sapiens
• Method
• small RNA-seq
• Tissue
• epididymis
• Quantity piRNA
• 968

22313525 Pubmed Informations
Retrieved from Pubmed website

• Title
• Deep sequencing analysis of small non-coding RNAs reveals the diversity of microRNAs and piRNAs in the human epididymis.
• Publication Date
• 07/18/2012
• Abstract
• The epididymis plays a crucial role in regulating the development of sperm motility and fertilizing capacity. Small non-coding RNAs (sncRNAs), especially microRNAs (miRNAs), can participate in the regulation of various physiological pathways. However, their abundance and whether they are involved in the regulation of gene expression in the human epididymis are unknown. By adopting the Solexa deep sequencing approach, we systematically investigated the sncRNAs in the adult human epididymis. A total of 4903 unique sequences representing 527 known miRNA were discovered. Eighteen novel miRNA genes encoding 23 mature miRNAs were also identified and the expression of some of them was confirmed by qRT-PCR. The presence of Piwi-interacting RNAs (piRNAs) in the library also adds to the diversity of the sncRNA population in the human epididymis. This research will contribute to a preliminary database for their functional study in male reproductive system.
• Author(s)
• Li, Yan; Wang, Hai-Yan; Wan, Feng-Chun; Liu, Fu-Jun; Liu, Juan; Zhang, Na; Jin, Shao-Hua; Li, Jian-Yuan;